Natural Chalcanthite crystals are very rare in nature. Well-formed crystals are easily grown synthetically from copper sulfate solutions. This can be done by dissolving a readily available chemical salt called copper sulfate, and then letting the water evaporate. This leaves behind a crystallized mass of Chalcanthite which can crystallize beautifully if grown properly. If a Chalcanthite crystal looks to good to be natural, it probably is, as good natural crystals are very hard to come accross. Unscrupulous mineral dealers have been known to sell large, synthetic Chalcanthite specimens without indicating that they are not natural.

Chalcanthite generally forms in arid regions and dry caves which are protected from moisture. It commonly forms stalactitic and botryoidal growths on the walls and ceilings of mine tunnels from the oxidation of copper sulfide minerals. Chalcanthite specimens must be kept away from water and moist conditions, since a chemical effect with water causes them to eventually crumble or dissolve. Some collectors specimens are coated with mineral oil and sprayed with laquer to seal the mineral and prevent it from absorbing water. Chalcanthite is a very fragile mineral, and care should be taken when handling any specimen.